E3 Triage
The human E3 ligase repertoire ranked on ligandability, structural coverage, expression selectivity and family. Every component of the score is a visible column: there is no hidden scoring.
638
ligases
638
with a pocket score
57
orphan
2
clinically validated
Ranking weights
Read live from config/thresholds.toml. Every component is a
visible column in the table: there is no hidden scoring. The spec 9.3
enrichment test runs with exploitation_status and
has_ligand held out of these weights, otherwise it would be
circular.
| Component | Weight |
|---|---|
| expression selectivity | 0.2 |
| family novelty | 0.1 |
| pocket score | 0.3 |
| pocket volume | 0.1 |
| structural coverage | 0.15 |
| substrate count | 0.15 |
Pin a ligase to load its best structure. The top fpocket pocket renders as a surface mesh, any bound drug-like ligand is shown, and the pocket volume and score appear in the overlay.