Degradability
Surface lysine accessibility and geometry relative to a chosen binding site: the question that kills degrader programmes late and is rarely asked at nomination.
1,650
unclassified
Reach window
The reach window has not been fitted.
not yet fitted. The starting values in
config/thresholds.toml carry no empirical standing and are
not used to produce a verdict, so no verdict column is shown until the fit
lands. This is deliberate: spec 5.4 forbids shipping the starting values.
Honest limits of this metric.
Observed ubiquitylation sites come from native E3 biology, not from induced
ternary complexes, so the window is a proxy. Absence of a reported site is weak
evidence that a lysine is unusable, because detection is incomplete and
condition-dependent, and that biases the negative set. Read the AUC as a
measure of enrichment, not as a probability of degradability.
Pin a target and a site to load its surface. Every lysine NZ renders as a sphere coloured by verdict, the site centroid is marked, and a measurement line runs from the selected lysine to the centroid with the distance in Å.